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Don’t miss our Summer Sale. Stay ahead of the stories that are shaping our world – and what they mean for you.
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Laura Donnelly Health Editor |
Today, The Telegraph reveals the launch of a landmark global trial that will interest many families affected by dementia – including mine.
From Monday, healthy middle-aged people in Britain will begin being screened to see if drugs can stop Alzheimer’s even before memory problems emerge.
The PrevenTron study will give trontinemab to people aged between 55 and 80 who have no cognitive symptoms but whose blood tests show biological signs associated with Alzheimer’s.
Around 1,600 volunteers will take part internationally, including at more than 15 centres in Britain, with an NHS trust in Surrey the first in Europe to start recruiting.
The drug attacks amyloid, the sticky protein that forms plaques in the brain. Early research found that high doses could clear these plaques after just three monthly infusions – far faster than existing treatments.
Scientists will monitor participants for four to six years to see whether such early intervention can prevent or delay problems with memory and thinking.
It is a striking shift. Currently, patients only receive Alzheimer’s drugs once symptoms have developed, by which point the disease may have been progressing silently for years. The hope is that blood tests could eventually identify those at greatest risk while they are still well, allowing preventive treatment akin to “statins for the brain”.
The trial remains experimental, but for families who have watched dementia affect one generation, its ambition will feel intensely personal.
This exclusive report is available only to subscribers.
Continue reading ➤ |
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Camilla Tominey Farage must reflect seriously on a series of self-inflicted errors that are exposing his party as unfit for government Continue reading ➤
Stephen Pollard Miriam Margolyes isn’t a national treasure, she’s an irrational disgrace Continue reading ➤
Charles Moore With Milei, Trump and our defeatist culture, could we lose the Falklands all over again? Continue reading ➤ |
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• Two senior Reform UK aides have stepped down over what Nigel Farage has described as “loose pub talk”, in response to allegations that the party breached political donation rules.
• A Russian drone has struck the headquarters of Ukraine’s security services in Kyiv. Volodymyr Zelensky said the attack was an assassination attempt.
• Natural England has been accused of “bullying” rural workers in a legal battle over a crackdown on shooting. A High Court judge said that the watchdog should avoid “idle threats”.
• A school trust chief who called parents “scrotes, vermin and pond life” has been banned from teaching. Lee Hessey also said he hoped Ofsted inspectors would go under a lorry on black ice.
• Finally, today marks the final episode of Geoffrey Boycott: An Extraordinary Innings. In it, Boycott reveals his passion for the Chinese way of life and his views on diversity on TMS. Listen now. |
Amid a party funding scandal and falling poll numbers, Reform UK’s combative home affairs spokesman talks to Annabel Denham, our Senior Political Commentator, about “establishment” attacks, his no-holds-barred approach to politics and why he has never been more convinced that Nigel Farage is on his way to Downing Street. Continue reading ➤ |
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It sounds like the plot from an episode of Black Mirror: a swarm of AI robots learn how to communicate with each other, cheat the research task they have been given and join forces to hack into a platform known as Hugging Face. In fact, this is what happened in May. Experts have warned that the world is now on the verge of a silent “takeover”, with machines in power and humans at their mercy. Natasha Leake reports. Continue reading ➤ |
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Fun fact: Natalie Imbruglia’s 1998 album Left of the Middle is the bestselling debut album by an Australian female artist of all time. Not bad for the girl next door from Neighbours who was forced to audition for the soap opera in a bikini. She also tells Eleanor Halls about single motherhood, her menopausal new album and what happened when she agreed to pose for a lads’ mag... Continue reading ➤ |
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Google and Apple have bowed to Donald Trump’s order to rename Lake Ontario as Lake America on their maps. Others are determined to ignore him. The US leader’s desire to write history through geography, however, is nothing new. Here, Iain Hollingshead looks at how, over the last two millennia, these changes rarely go as planned. Continue reading ➤ |
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Losing weight is simple on paper. Keeping it off is where things get difficult. Fat-loss coach Emma Storey-Gordon has spent 15 years helping clients make healthy eating fit around real life – without giving up dinners out or feeling like they’re constantly on a diet. Here’s how she does it. Continue reading ➤ Here is another article that I hope you will find helpful this morning:
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Do you know what you’re going to eat this weekend? We’ve got you covered. Every week, Diana Henry, The Telegraph’s award-winning cookery writer, brings you three recipes for a perfect weekend meal. Meanwhile, William Sitwell shares his view from the culinary world – and a recommendation or two.
Spelt with blackberries, beetroot, walnuts and buttermilk |
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Diana Henry |
Even though the weather has turned autumnal – it’s still warm, but there’s been a definite shift – there are foods I don’t want to let go of. Phrases like “summer’s last stand” and “the last hurrah” swim in my head, especially when I’m in a greengrocer’s. There, I hunt for fruit and veg that will help me straddle the changing seasons.
Cultivated blackberries are around all year now, of course, but there are still some wild ones near where I live. So I’ll be making a salad of blackberries, beetroot and spelt, with a buttermilk dressing. If you’re also using wild berries you have a little window in which you can still produce this – a lovely late summer/early autumn dish.
Crab and corn risotto with crème fraîche and cayenne butter |
I keep all my recipes – and there are hundreds – in documents on my laptop. These are not arranged in a sensible way. I recently managed to unearth a favourite: crab and sweetcorn risotto with crème fraîche and cayenne butter. This is not an Italian dish, but rather an American one. A love of American restaurants and the work of American food writers means I love dishes that smack of a warm September in Portland or San Francisco. This one has so many contrasting flavours. The crème fraiche with cayenne butter is optional but it takes a simple risotto to a new level.
Roasted peaches with praline cream |
Stone fruit are what I miss most once the summer has gone. I can tell that nectarines are on their way out – you gradually start to notice that their sweetness fades and the flesh turns a bit pappy. It’s the same with peaches. I need to make a final dessert with stone fruit... let’s go for roasted peaches with praline cream. You can use either nectarines or peaches for this dish. The praline nudges things gently towards autumn.
Bye bye, summer. See you next year.
Find me here every Saturday and in my Recipes newsletter, which you can sign up to here.
Meanwhile, William Sitwell muses on the unwritten rules of bringing dogs along to eat
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William Sitwell |
It’s a familiar scene in my restaurant, The White Hart, in West Somerset. Slim Shady and Papa Leone languishing on the floor of the bar. They’re not rappers or popes, but whippets owned by some beloved regulars. Until now, the bar is where they must dwell. For, as goes the lore in hospitality, it’s dogs in the bar, humans only in the dining room. I’m in charge, however, so I make the rules at my place. So from now on, your pooches can accompany you into the plush confines of our dining room. Woof woof!!
Read William’s full column ➤ |
Jet settersEvery weekday, Orlando Bird, our loyal Reader Correspondent, shares an off-piste topic that has brought out the best of your opinions and stories. Orlando writes...
Thanks for all your responses to this week’s newsletters. Wednesday’s edition confirmed that, when it comes to airports, Telegraph readers firmly believe that small is beautiful (if not always slickly organised).
“Having been ‘collecting’ airports throughout my adult life,” writes Alan Forbes, “and having more than 1,070 to my name, I can suggest many small ones. They include Papa Westray in Orkney, St Barts in the Caribbean and Ba’kelalan in Malaysia. All are just dreamy.”
Patrick Hodgson recalls: “In Sierra Leone in the 1970s, I had to meet the Queen’s Messenger off the British Caledonia flight once a week at Lungi airport. The departure lounge was a tin hut, but we were allowed to use the VIP area – another hut, but with a ceiling fan and a fridge full of cola and beer.”
Yanky Fachler adds: “I was once the only passenger on an evening flight to a tiny US airport. The promised cab was not there. The airport manager took pity on me. He turned off the lights, locked up and drove me to my hotel.”
That’s service. Finally, another reader advises: “You haven’t lived until you’ve flown to Tresco in the Isles of Scilly by helicopter from Penzance. It is the most adorable heliport with fantastic staff, a great café with homemade cakes and easy parking. The flight takes you along the Cornish coast and out to sea, landing next to the amazing Tresco Abbey Gardens. Paradise. Add it to your bucket list.” That’s all from me for this week, folks. I’ll be back on Monday to bring you the best Telegraph talking points. In the meantime, you can contact me here.
Please confirm in your reply that you are happy to be featured and that we have your permission to use your name. |
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Welcome to Andrew Baker’s Saturday quiz. Test your knowledge below to see if you have been paying attention to our newsletters this week...
1. Nottingham council plans to ban what from the city’s streets?
2. The Daily T went on the road to the Reform UK party conference. In which city?
3. We tested Dyson’s new personal care product, costing £420. What is it?
4. Reader John Naylor, from coastal East Sussex, is convinced that he heard the phrase “choose your own lipstick” from which unlikely source?
5. What is the name of the British company, named after a penguin, that is leading the search for oil off the Falkland Islands?
Find as many words as you can in today’s Panagram, including the nine-letter solution. Visit Telegraph Puzzles to play a range of head-scratching games, including The 1% Club, Cogs, and Quick, Mini or Cryptic Crosswords.
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Yesterday’s Panagram was TAILGATED. Come back tomorrow for the solution to today’s puzzle.
Plus, can you tackle The 1% Club? Scroll down to see if you got the questions right – and play for free on our website and app.
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1972 | Israeli athletes are taken hostage and killed at the Munich Olympics (you can see how we covered this the following day)
1976 | The first episode of The Muppet Show airs
2022 | Liz Truss is elected as the next leader of the Conservative Party, succeeding Boris Johnson
2025 | Angela Rayner quits as deputy prime minister after a Telegraph investigation reveals that she failed to obtain proper tax advice on the purchase of her seaside flat (you can also see how we covered this below)
Birthdays | Sigrid (30), Rose McGowan (53), Michael Keaton (75)
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Thank you for reading. Have a fulfilling day and I hope to see you tomorrow. Chris Evans, Editor
P.S. Please send me your thoughts on this newsletter. You can email me at fromtheeditor@telegraph.co.uk. |
Quiz answers:
- Balaclava helmets
- Birmingham
- Toothbrush
- A seagull
- Rockhopper
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The 1% Club answers:
- Song five
- Travel overseas
- E
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Don’t miss our Summer Sale. Stay ahead of the stories that are shaping our world – and what they mean for you.
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